This is such a fascinating setting and story ai dont know where to begin aside from just gushing about it!
One of the things I like about this one is that the fact that the setting is so pulpy allows it to get to some really dark content without becoming too 'real'. Compared to other freeuse stories, which historically haven't really done it for me, in this one the whole thing is routine, but not altogether unquestioned and unremarked upon. I like exploring the agency of the viewpoint characters, and it provides opportunities for both conflict and humor.
One setting question I have which came up in the last chapter is how fantastic the technology should be. It seems to be a given that medicine and engineering are very advanced and can do whatever the story needs them to - at the very least, STDs seem to have been eradicated -but what about things that outright break the laws of physics, like the infamous helicarrier from marvel comics? I recall "Mengele's monsters" being mentioned in a newsreel - are there 'bioshock' levels of magical genetics going about?
The general rule of thumb Ill go with is if someone has seriously proposed a piece of tech, no matter how outlandish and impractical, it is obviously fair game, but otherwise to try and avoid adding any more comic book science than strictly necessary.